Showing posts with label drug. Show all posts
Showing posts with label drug. Show all posts

Gymnema Sylvestre to Treat Diabetes - Reduce Sugar

A new treatment to reduce the number of obese people is to be instigation world wide. Gymnema Sylvestre is a woody plant. Acids in the extract from it are similar to sweet detectors on the tongue. They block these taste buds. There is also research into using the herb for diabetes control.

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show more read reviews 59 overview uses side effects interactions dosing overview overview information gymnema woody climbing shrub native india africa leaves used make medicine gymnema has long history india ayurvedic medicine hindi name gymnema means destroyer sugar people gymnema diabetes weight loss conditions but there good scientific evidence support uses work gymnema contains substances decrease absorption sugar from intestine gymnema may increase amount insulin body increase growth cells pancreas place body insulin made uses uses effectiveness insufficient evidence diabetes early research shows taking gymnema mouth along insulin diabetes medications improve blood sugar control people type type diabetes metabolic syndrome early research shows taking gymnema 12 weeks reduce body weight body mass index overweight people metabolic syndrome but gymnema not appear help blood sugar control improve cholesterol levels people weight loss early research shows taking gymnema 12 weeks reduce body weight body mass index people overweight early research shows taking combination gymnema hydroxycitric acid niacin-bound chromium mouth reduce body weight people overweight obese cough increasing urine excretion diuretic malaria metabolic syndrome snake bites softening stool laxative stimulating digestion more evidence needed rate gymnema uses side effects side effects safety gymnema possibly safe taken mouth appropriately 20 months special precautions warnings pregnancy breast-feeding there not enough reliable information safety taking gymnema you pregnant breast feeding stay safe side avoid diabetes gymnema lower blood sugar levels people diabetes watch signs low blood sugar hypoglycemia.

monitor blood sugar carefully you have diabetes gymnema surgery gymnema affect blood sugar levels interfere blood sugar control during surgical procedures stop using gymnema least weeks scheduled surgery interactions interactions moderate interaction cautious combination insulin interacts gymnema gymnema decrease blood sugar insulin used decrease blood sugar taking gymnema along insulin cause blood sugar low monitor blood sugar closely dose insulin need changed medications diabetes antidiabetes drugs interacts gymnema gymnema supplements seem lower blood sugar people diabetes diabetes medications used lower blood sugar taking gymnema along diabetes medications cause blood sugar go low monitor blood sugar closely dose diabetes medication need changed medications used diabetes include glimepiride amaryl glyburide diabeta glynase prestab micronase insulin pioglitazone actos rosiglitazone avandia chlorpropamide diabinese glipizide glucotrol tolbutamide orinase others dosing dosing appropriate dose gymnema depends several factors user age health several conditions time there not enough scientific information determine appropriate range doses gymnema keep mind natural products not always necessarily safe dosages important sure follow relevant directions product labels consult pharmacist physician healthcare professional using previous next uses view references references ananthan r latha pari ramkumar baskar c g bai v effect.

gymnema montanum blood glucose plasma insulin carbohydrate metabolic enzymes alloxan-induced diabetic rats j med food 2003 43-49 view abstract baskaran ahamath bk shanmugasundaram kr et antidiabetic effect leaf extract from gymnema sylvestre non-insulin-dependent diabetes mellitus patients j ethnopharm 1990 30 295-305 bishayee chatterjee hypolipidaemic antiatherosclerotic effects oral gymnema sylvestre r br leaf extract albino rats fed high fat diet phytother res 1994 118-120 chattopadhyay rr possible mechanism antihyperglycemic effect gymnema sylvestre leaf extract part gen pharm 1998 31 495-496 gholap kar effects inula racemosa root gymnema sylvestre leaf extracts regulation corticosteroid induced diabetes mellitus involvement thyroid hormones pharmazie 2003 58 413-415 view abstract gupta ss variyar mc experimental studies pituitary diabetes iv effect gymnema sylvestre coccinia indica against hyperglycemia response somatotrophin corticotrophin hormones indian j med res 1964 52 200-207 jiang h advances study hypoglycemic constituents gymnema sylvestre retz schult zhong.yao cai 2003 26 305-307 view abstract khare ak tondon rn tewari jp hypoglycaemic activity indigenous drug gymnema sylvestre gurmar normal diabetic persons indian j physiol pharm 1983 27 257-258 kothe uppal r antidiabetic effects gymnema sylvestre.

short study indian j homeopath med 1997 32 1-2 61-62 66 murakami murakami kadoya et new hypoglycemic constituents gymnemic acid from gymnema sylvestre chem pharm bull 1996 44 469-471 okabayashi y tani fujisawa koide hasegawa h nakamura fujii otsuki effect gymnema sylvestre r.br glucose homeostasis rats diabetes res clin pract 1990 143-148 view abstract porchezhian dobriyal r overview advances gymnema sylvestre chemistry pharmacology patents pharmazie 2003 58 5-12 view abstract preuss h g garis r bramble j d bagchi d bagchi rao c v satyanarayana efficacy novel calcium potassium salt -hydroxycitric acid weight control int.j clin.pharmacol.res 2005 25 133-144 view abstract shanmugasundaram erb gopinath kl shanmugasundaram kr et al possible regeneration islets langerhans streptozotocin-diabetic rats given gymnema sylvestre leaf extracts j ethnopharm 1990 30 265-279 shanmugasundaram erb rajeswari g baskaran et al gymnema sylvestre leaf extract control blood glucose insulin-dependent diabetes mellitus j ethnopharm 1990 30 281-294 shanmugasundaram kr panneerselvam c samudram et al enzyme changes glucose utilisation diabetic rabbits effect gymnema sylvestre r.br j ethnopharm 1983 205-234 sinsheimer je rao gs mcilhenny hm constituents from gymnema sylvestre.

leaves v isolation preliminary characterization gymnemic acids j pharm sci 1970 59 622-628 srivastava y bhatt hv prem et al hypoglycemic life-prolonging properties gymnema sylvestre leaf extract diabetic rats israel j med sci 1985 21 540-542 terasawa h miyoshi imoto effects long-term administration gymnema sylvestre watery-extract variations body weight plasma glucose serum triglyceride total cholesterol insulin wistar fatty rats yonago acta med 1994 37 117-127 tominaga kimura sugiyama et al effects seishin-renshi-in gymnema sylvestre insulin resistance streptozotocin-induced diabetic rats diabet res clin pract 1995 29 11-17 wang lf luo h miyoshi et al inhibitory effect gymnemic acid intestinal absorption oleic acid rats j physiol pharmacol 1998 76 1017-1023 xie j wang mehendale wu j aung h h dey qiu yuan c anti-diabetic effects gymnema yunnanense extract pharmacol res 2003 47 323-329 view abstract yoshikawa murakami kadoya li y murakami yamahara j matsuda h medicinal foodstuffs ix inhibitors glucose absorption from leaves gymnema sylvestre r br asclepiadaceae structures gymnemosides chem.pharm bull tokyo 1997 45 1671-1676 view abstract ananthan r baskar c narmathabai v et al antidiabetic effect gymnema montanum leaves effect lipid peroxidation induced oxidative stress experimental diabetes pharmacol res 2003 48 551-6 view abstract arunachalam kd arun lb annamalai sk arunachalam potential anticancer properties bioactive compounds gymnema sylvestre its biofunctionalized silver nanoparticles int j nanomedicine 2014 31-41.

view abstract baskaran kizar ahamath radha shanmugasundaram shanmugasundaram er antidiabetic effect leaf extract from gymnema sylvestre non-insulin-dependent diabetes mellitus patients j ethnopharmacol 1990 30 295-300 view abstract fabio gd romanucci v de marco zarrelli triterpenoids from gymnema sylvestre their pharmacological activities molecules 2014 19 10956-81 view abstract head ka type diabetes prevention disease its complications townsend letter doctors patients 1998 180 72-84 kamble gupta moothedath khatal janrao jadhav et al effects gymnema sylvestre extract pharmacokinetics pharmacodynamics glimepiride streptozotocin induced diabetic rats chem biol interact 2016 245 30-8 view abstract katsukawa h imoto ninomiya y induction salivary gurmarin-binding proteins rats fed gymnema-containing diets chem senses 1999 24 387-92 view abstract luo h kashiwagi shibahara yamada decreased bodyweight without rebound regulated lipoprotein metabolism gymnemate genetic multifactor syndrome animal mol cell biochem 2007 299 93-8 view abstract nakamura y tsumura y tonogai y shibata fecal steroid excretion increased rats oral administration gymnemic acids contained gymnema sylvestre leaves j nutr 1999 129 1214-22 view abstract persaud sj al-majed h raman jones pm gymnema sylvestre stimulates insulin release vitro increased membrane permeability j endocrinol 1999 163 207-12 view abstract preuss hg bagchi d bagchi et al effects natural extract -hydroxycitric acid hca-sx combination hca-sx plus niacin-bound chromium gymnema sylvestre extract weight loss diabetes obes metab 2004 171-180 view abstract rammohan samit chinmoy d et al.

human cytochrome p450 enzyme modulation gymnema sylvestre predictive safety evaluation lc-ms ms pharmacogn mag 2016 jul 12 suppl s389-s394 view abstract satdive rk abhilash fulzele dp antimicrobial activity gymnema sylvestre leaf extract fitoterapia 2003 74 699-701 view abstract shanmugasundaram er rajeswari g baskaran et al gymnema sylvestre leaf extract control blood glucose insulin-dependent diabetes mellitus j ethnopharmacol 1990 30 281-94 view abstract shiyovich sztarkier nesher toxic hepatitis induced gymnema sylvestre natural remedy type diabetes mellitus j med sci 2010 340 514-7 view abstract singh vk dwivedi chaudhary br singh r immunomodulatory effect gymnema sylvestre r.br leaf extract vitro study rat model plos 2015 10 e0139631 view abstract sinsheimer je subba-rao g mcilhenny hm constitents from g sylvestre leaves isolation preliminary characterization gymnemic acids j pharmacol sci 1970 59 622-8 tiwari mishra bn sangwan ns phytochemical pharmacological properties gymnema sylvestre important medicinal plant biomed res int 2014 2014 830285 view abstract vaghela iyer pandita vitro inhibitory effect gymnema sylvestre extracts total gymnemic acids fraction select cytochrome p450 activities rat liver microsomes eur j drug metab pharmacokinet 2017 oct view abstract vaghela sahu kharkar pandita vivo pharmacokinetic interaction ethanolic extract gymnema sylvestre cyp2c9 tolbutamide cyp3a4 amlodipine cyp1a2 phenacetin.

rats chem biol interact 2017 dec 25 278 141-151 view abstract yeh gy eisenberg dm kaptchuk tj phillips rs systematic review herbs dietary supplements glycemic control diabetes diabetes care 2003 26 1277-94 view abstract zuniga ly gonzalez-ortiz martinez-abundis effect gymnema sylvestre administration metabolic syndrome insulin sensitivity insulin secretion j med food 2017 aug 20 750-54 view abstract more resources gymnema reviews 59 interaction checker search another vitamin alpha lipoic acid apple cider vinegar black cohosh calcium chromium coenzyme q ‒ dhea flaxseed folic acid ginko glucosamine melatonin niacin magnesium probiotics red yeast rice st john wort vitamin c vitamin d vitamin show more show less you like choose vitamins supplements vitamins you need you age habits longer life non-drug migraine treatments alternative treatments migraines alternative treatments ibs-d eat stay sharp longevity diet dangers high potassium potassium high find more vitamins used treat conditions diabetes metabolic syndrome weight loss show more show less conditions important information information meant supplement not replace advice from doctor healthcare provider not meant cover possible uses precautions interactions adverse effects information may not fit specific health circumstances never delay disregard seeking professional medical advice from doctor qualified health care provider because something you have read webmd you should always speak doctor health care professional.

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Gimnema

GM Not for Food Okay for Health

Genetic modification is favored in health but not for food.
Convincing people to eat genetically modified food still has a long way to go to gain majority acceptance. Yet, just about everyone is in favor of using gene technology to treat health problems. This is a strange anomaly. Gene manipulation of any kind will change the world we live in. Once a change has been made and it spreads through the environment it is there forever.
The case against genetically modified crops, GMCs
Drug companies admit they have lost the war in Europe. There is no way that GM food will ever be accepted there. It is largely an emotional decision, not scientifically based. Possibly, in the near future, Europe will ban DNA experimentation in health as well. This will be counter-productive. If money is invested in nations that welcome gene science then the environment will change anyway because we all live in the same world.

There is a major problem looming, however, on the real future of genetically modified crops. To be profitable farmers must use Monsanto's Roundup. This is losing its effectiveness, particularly in Western Australia which has recently relaxed laws restricting GMCs. The cart isn't much use without the horse.  Even crops modified to be resistant against glyphosate could become weeds in the future.  Unless a new effective herbicide is developed soon the industry will not attract investors - potential profit drives everything.
 Gemetics by Ty Buchanan 
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GM MAYBE
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Legalize Marijuana - Be Careful What You Wish For!

Ninety three percent of Australians support the adoption of marijuana for medical use. This is despite the fact that no trial has shown any pain relieving properties in the drug whatsoever.  So we are going to relax the driving laws to allow people under the influence to drive - not bloody likely!
Marijuana for medical use
Can you imagine a guest at a party making a fool of himself while taking marijuana with others powerless to do anything about it? Sure, the drug makes you relaxed and dopey, but that is no excuse to force it on passersby.

It is not the genuine patients with cancer, Parkinson's disease, or glaucoma that may benefit from its improved well being properties, what we have to be careful of is doctor shoppers who go around pestering GPs to write scripts, like the current situation for opiates.

The government is planning to legalized marijuana for medical use. let us hope that tough safeguards are in place to block access to those in the general public who are only after a quick high.
Society by Ty Buchanan
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MARIJUANA NOW
 #marijuana #drug #treatment #medical #reasons #doctor #prescription  

New Finding for Dengue Haemorrhagic Fever

Catching dengue fever is a constant fear in Australia. Like malaria it is spread by mosquitoes. Its full name Dengue Haemorrhagic Fever. You can become very sick indeed if you develop the hemorrhagic form, though it seldom causes death.
A patient with Dengue Haemorrhagic Fever showing red spots of hemorrhage
Drugs made for sepsis infection are being used to treat dengue in mice. They has yet to be used on humans. Hopefully new methods for early detection and treatment with drugs will stop progression to the severe dengue.

A new finding could move treatment along a bit. The dengue virus NS1 protein causes immune cells to "leak" blood vessels. TLR4 is the pathway that triggers the response. Some existing drugs do block this pathway. Ironically, many of them did not stop sepsis. They were failures!

Other diseases also use the NS1 method of infection. Work has to be done to explore the battery of drugs already available to hopefully find successful treatments for these related illnesses.
Chemistry by Ty Buchanan
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SIGNIFICANT FINDING ABOUT DENGUE FEVER

Complacency and Support for Drug Taking is Dangerous


We are far too complacent about drug taking, assuming that we can just stop at any time. With alcohol use it is clear that this is not the case. Road breath tests frequently find no alcohol in a driver's system, but a drug test shows up positive. It seem that drugs can be substituted for alcohol. So it is wise not to take any drugs even as an experiment.

Drug addiction is not rare for the number of drug takers out there. Many think they can stop. They cannot. Even taking drugs regularly in the short term means withdrawal with occur. Furthermore, there is no know real cure apart from complete abstinence.

Not much is written about the health risks from drug taking. Many believe that smoking cannabis is completely safe. However, all the problems of smoking tobacco are possible.  All illicit drugs destroy the body.  Drugs are poison, just like alcohol.  Take them at your peril.

Another real issue is permanent damage in brain functioning that can affect national economies. Forgetfulness and lack of emotional control do not make for success in the workforce. Someone has to pay for supporting those who cannot function "correctly" in society.

Drug taking is destroying societies. Take an illegal drug once and you are hooked. You will come back to it when times get tough. People who take drugs are looking for a crutch. The truth is drug takers soon fall out of the workforce and can no longer contribute.
Science by Ty Buchanan
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We are Heading Toward a Drugged-Up World

A new survey has found that school children under 17 years who smoke cannabis are less likely to complete their high school education. This is not surprising as cannabis "kills" the rational part of the brain and makes users impulsive, unable to control their actions.

Addicts are driven through a path in life from one pleasurable thing to another. They avoid all uncomfortable situations immediately, seeking the nearest pleasure at hand. This is why they end up breaking the law and becoming incarcerated.

Suicide is high amongst cannabis users because good experiences are not always for the taking. When one works at a job it is not pleasant, nor is it truly sought after. However, unless the discomfort is suffered there will be no pleasure from spending the income.

Legalization for medical use is another step toward general access. Many young people are already unfit for the workforce because schools do not teach work related skills. Education needs radical reform. We need to turn the clock back. Get rid of the choice subjects and make all students do fundamental, core subject like in the old days. Rote is not a dirty word. Every older person knows the twelve times table by heart even in old age. Having all student repeat things out loud, together is a good thing. How are they to discover the answers on their own?

Like in ancient days in China when people spent their days slothfully wasting time sitting under a tree waiting for ripe fruit to fall, we are heading toward a world where everyone expects welfare and someone else will do the work. Drug taking is bringing this closer.
 Culture by Ty Buchanan 
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Should the Government Pay for Ipilimumab?

How can the state pay for drugs that are shown to be effective against disease but cost far too much? Regularly, someone will be on a current affairs television program and point their finger at the government for not continuing to supply their needed medication. In the long term a government must balance the books. There is simply not enough revenue to provide new expensive drugs.

A new treatment for melanoma called Ipilimumab is very effective, but it costs $120,000 for a three month course. It stops the cancer from spreading beyond the skin. Ipilimumab can also be used to treat some types of lung cancer.

Should the government subsidize this drug? Like all medications there are side effects that can be severe in some patients. Symptoms include constipation, diarrhea, urination complications, bloating, stomach pain, fever and breathing difficulties.

The drug usually extends life by several months. In some cases patients survive for a year. A value judgement is needed to decide whether this treatment is added to the pharmaceutical benefits list. Obviously, there are many new drugs that prolong life for a relatively short period. Personally, if I was to get melanoma I would not worry about extending my life for maybe a year. I would be looking at the quality of my final days of life.
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New Cancer Drug Announced in Melbourne

A new cancer drug has been announced by Cancer Therapeutics CRC in Melbourne. CTx-294886 is to be used in conjunction with another medication, Avastin. Furthermore, a new type of scanning has been developed by the same company. It will identify protein homeostasis, a new pathway in cancer treatment.

CTx-0294886 stops tumour growth by inhibiting Focal Adhesion Kinase (FAK) and Vascular Endothelial Growth Factor Receptor 3 (VEGFR3). This with Avastin reduces angiogenesis, slowing tumor growth in breast cancer. Examination of effects in head, neck and cervical cancers is ongoing.

The company has already developed a primary anti-cancer medication, CTx-294945). Both drugs can now be used to prolong life when dancer is detected. Research was done with the assistance of Australian and international institutions.
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Health

Muscles Created for Nanobots

Can nanobots have muscles? Researchers have made very strong, flexible muscles that could be used by nanobots to travel around the body diagnosing and treating medical conditions.

As flexible limbs much like octopus tentacles, artificial muscles can move objects a thousand times heavier. Thinner than a human hair, the "yarns" are cheap to make. They could potentially be used for pumps, valves, stirrers and flagella for drug discovery.

They were created by applying an electrochemical charge to spun carbon nanotubes making them twist into helical yarns. They are ideal to attach to bots as a tiny tail, a flagella, to propel the bot forward.

This was a truly international breakthrough. Participants in the work were the University of Wollongong, Australia, the University of Texas and Hanyang University of Korea.
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