Showing posts with label virus. Show all posts
Showing posts with label virus. Show all posts

New Finding for Dengue Haemorrhagic Fever

Catching dengue fever is a constant fear in Australia. Like malaria it is spread by mosquitoes. Its full name Dengue Haemorrhagic Fever. You can become very sick indeed if you develop the hemorrhagic form, though it seldom causes death.
A patient with Dengue Haemorrhagic Fever showing red spots of hemorrhage
Drugs made for sepsis infection are being used to treat dengue in mice. They has yet to be used on humans. Hopefully new methods for early detection and treatment with drugs will stop progression to the severe dengue.

A new finding could move treatment along a bit. The dengue virus NS1 protein causes immune cells to "leak" blood vessels. TLR4 is the pathway that triggers the response. Some existing drugs do block this pathway. Ironically, many of them did not stop sepsis. They were failures!

Other diseases also use the NS1 method of infection. Work has to be done to explore the battery of drugs already available to hopefully find successful treatments for these related illnesses.
Chemistry by Ty Buchanan
            Australian Blog   Adventure Australia
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Dengue Haemorrhagic Fever illness sick treatment ns1 tlr4 protein existing drugs death infection

Hendra Virus Similar to Nipah Disease in Asia

The Hendra virus was first identified in 1994. It killed horses and several veterinary scientists. Oddly, this deadly disease has only appeared in Australia. This is very unusual. Diseases tend to spread across national borders.

Outbreaks are spasmodic. Horses in Queensland and New South Wales have died recently in the latest outbreak. Scientists are intensively examining all aspects of the Hendra virus. A dog was found to be a carrier. Though unaffected and quite healthy the dog had to be put down.

Promising results have been obtained by using human antibody m102.4 on monkeys who were intentionally infected. The animals remained well for three days before needing treatment. All of the subjects survived. A control group of monkeys who were not given the antibody died.

Though unproven, the ailment is believed to be carried and spread by bats. A similar bat borne disease is widespread in India, Bangladesh and Malaysia. The Asian Nipah ailment identified in 1998 is of interest to scientists because aspects of it are much the same as the Hendra virus.
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