Showing posts with label inflammation. Show all posts
Showing posts with label inflammation. Show all posts

Vaccine for Rheumatoid Arthritis

Rheumatoid arthritis is a widespread complaint. It is usually a malady of the elderly, but the young can succumb to it too. About the only treatment available is replacement of joints with artificial ones and analgesics.
Rheumatoid arthritis treatment vaccine
A team at the University of Queensland has taken a new approach. They have developed a vaccine. Many diseases are caused by the body attacking its own tissue. Arthritis is one of these. If the immune response is suppressed, inflammation decreases. This is how the new vaccine works.

All Westerners have high inflammation levels. This may be a good thing to fight injuries. However, continued long term inflammation does damage to the body. Once switched on and the immediate danger solved it needs to be turned off.

The new method involves taking a sample of the patient's immune cells which are then modified in the lab. This is injected back into the patient. The immune system no longer sees the modified peptide as foreign.

Other problematic diseases due to a lingering immune response would seem to be future candidates for similar vaccines.
Health by Ty Buchanan
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            Australian Blog   Adventure Australia

DNA Readies You for the Winter

It is commonly believed that DNA does its job and is just "there", non-functioning. However, new research shows DNA to be pro-active. It reads our senses and reacts accordingly. DNA detects the seasons and changes ones' body chemistry accordingly.
DNA genes image img
As many as a fifth of all blood cells genes change with the season. Gene switches are turned on or off to achieve this. In winter immune responders are at a high level. The blood gets thinner in summer knowing that you will be more active. Body-building, fat-burning and water retention is the objective in hotter months.

It is possible that living in air conditioned buildings could leave you body at risk of disease because the preparatory changes are not complete. Even the length of day is now distorted by artificial light.  While having ant-inflammatory chemicals ready and operational in winter is rationally useful, inflammation in itself damages the body, particularly when there is no attack on the body.

It seems DNA knows what it is doing. This is not proven though. Body reactions have been developed by evolution. Remember, there have been dead ends where species have disappeared when the environment changed. Whether, white bread is safe to eat is still not known. Only 10,000 years of human consumption of this unnatural substance proves nothing.
Chemistry by Ty Buchanan
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            Australian Blog   Adventure Australia

Binge Drinking Causes Type 2 Diabetes

Drinking alcohol is not an innocent pastime. We know it damages the liver. However, a link has been found between binge drinking and the onset of type 2 diabetes. How it does this is not fully understood.

Rats were put on a "diet" of 3 g/kg of alcohol for only three days. Even when the alcohol had completely left their systems insulin resistance was still occurring. The effect lasted 54 hours after ingestion of alcohol had ceased.

Impaired adipose tissue and hepatic functions were believed to be the cause. There was more hypothalamic inflammation affecting insulin signaling.

There is hope for a treatment. Inhibiting brain protein tyrosine phosphatase 1B (PTP1B) can block the detrimental action  on insulin of binge drinking,
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