Wiki World: insulin

With today's technology why can't an artificial pancreas be put into a patient's body? Well, now it can! Xavier Hames is only four years old. Autoimmune disease has destroyed his pancreas. An artificial one is working very well indeed inside his body.

The artificial pancreas is more a computer than a body organ. It monitors low insulin levels, even predicting its future trends, then controls insulin delivery. It is particularly useful as night when external insulin treatment can fail resulting in a coma.

Preparations are in train to implant another artificial pancreas in an adult, Jane Reid. This could mean an end to eight jabs a day to test blood levels of insulin and continuous injections to control it. This could save governments millions of dollars in the long term.

✴ Health by Ty Buchanan ✴

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Drinking alcohol is not an innocent pastime. We know it damages the liver. However, a link has been found between binge drinking and the onset of type 2 diabetes. How it does this is not fully understood.

Rats were put on a "diet" of 3 g/kg of alcohol for only three days. Even when the alcohol had completely left their systems insulin resistance was still occurring. The effect lasted 54 hours after ingestion of alcohol had ceased.

Impaired adipose tissue and hepatic functions were believed to be the cause. There was more hypothalamic inflammation affecting insulin signaling.

There is hope for a treatment. Inhibiting brain protein tyrosine phosphatase 1B (PTP1B) can block the detrimental action on insulin of binge drinking,